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Chemical Structure : Embelin
CAS No.: 550-24-3
Catalog No.: PC-45289Not For Human Use, Lab Use Only.
Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties, specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | $238 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties, specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM).
Embelin has anti-inflammatory activities in both acute and chronic irritant contact dermatitis in vivo.
Embelin also inhibits plasminogen activator inhibitor-1 (PAI-1) with IC50 of 1.62 uM.
| M.Wt | 294.3859 | |
| Formula | C17H26O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl- |
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1. Siegel C, et al. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7.
2. Kalyan Kumar G, et al. Eur J Pharmacol. 2011 Jul 15;662(1-3):63-9.
3. Lin Z, et al. Chem Biol. 2013 Feb 21;20(2):253-61.
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