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Chemical Structure : Erlotinib
CAS No.: 183321-74-6
Catalog No.: PC-45893Not For Human Use, Lab Use Only.
A potent, selective inhibitor of EGFR with IC50 of 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 500 mg | $56 | In stock |
Bulk size, bulk discount!
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A potent, selective inhibitor of EGFR with IC50 of 2 nM; reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM; inhibits the proliferation of DiFi human colon tumor cells at submicromolar concentrations in cell culture and blocks cell cycle progression at the G1 phase; 100mg/kg completely prevents EGF-induced autophosphorylation of EGFR in human HN5 tumors growing as xenografts in athymic mice and of the hepatic EGFR of the treated mice; orally active.
Lung Cancer
Approved
| M.Wt | 393.4357 | |
| Formula | C22H23N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)- |
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1. Ng SS, et al. Mol Cancer Ther. 2002 Aug;1(10):777-83.
2. Moyer JD, et al. Cancer Res. 1997 Nov 1;57(21):4838-48.
3. Pollack VA, et al. J Pharmacol Exp Ther. 1999 Nov;291(2):739-48.
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