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Chemical Structure : Evofosfamide
CAS No.: 918633-87-1
Catalog No.: PC-42644Not For Human Use, Lab Use Only.
A potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $224 | In stock | |
| 50 mg | $624 | In stock | |
| 100 mg | $976 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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A potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes; inhibits H246 cells and HT29 cells with IC50 of 0.1 uM and 0.2 uM respectively; active in an in vivo MIA PaCa-2 pancreatic cancer orthotopic xenograft model.
Pancreatic Cancer
Phase 3 Clinical
| M.Wt | 449.0362 | |
| Formula | C9H16Br2N5O4P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO; H2O: 0.14 mg/mL |
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| Chemical Name/SMILES |
Phosphorodiamidic acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester |
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1. Duan JX, et al. J Med Chem. 2008 Apr 24;51(8):2412-20.
2. Hu J, et al. Blood. 2010 Sep 2;116(9):1524-7.
3. Meng F, et al. Mol Cancer Ther. 2012 Mar;11(3):740-51.
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