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Chemical Structure : FGF-401
CAS No.: 1708971-55-4
Catalog No.: PC-42406Not For Human Use, Lab Use Only.
FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | $988 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM; shows >1,000-fold selectivity against of panel of 65 kinases and in a kinome of 456 kinases; potently inhibits phospho-FGFR4 in vivo, exhibits anti-tumor activity in s several xenograft animal models.
Liver Cancer
Phase 2 Clinical
| M.Wt | 506.567 | |
| Formula | C25H30N8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6 mg/mL (Need Ultrasonic) |
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| Chemical Name/SMILES |
1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]- |
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1. Diana Graus Porta, et al. Abstract 2098: NVP-FGF401, a first-in-class highly selective and potent FGFR4 inhibitor for the treatment of HCC, AACR.
2. Patent WO2015059668A1, compound example 83.
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