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Chemical Structure : FIN-56
CAS No.: 1083162-61-1
Catalog No.: PC-60374Not For Human Use, Lab Use Only.
FIN-56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | Get quote |
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FIN-56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4.
FIN-56 also binds to and activates squalene synthase, an enzyme involved in the cholesterol synthesis, to suppress non-steroidogenic metabolites-most likely coenzyme Q10.
FIN-56 the mechanism involves two distinct pathways: one pathway is degradation of GPX4, which requires the enzymatic activity of ACC.
FIN-56has the other pathway is activation of SQS, which leads to coenzyme Q10 depletion.
| M.Wt | 517.66 | |
| Formula | C25H31N3O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide |
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1. Shimada K, et al. Nat Chem Biol. 2016 Jul;12(7):497-503.
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