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Chemical Structure : FL-411
CAS No.: 2118944-88-8
Catalog No.: PC-62636Not For Human Use, Lab Use Only.
FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells.
FL-411 induces ACD pathways involved in HMGB1, VDAC1/2, and eEF2.
FL-411 displays a therapeutic potential on both breast cancer xenograft mouse and zebrafish models.
| M.Wt | 341.429 | |
| Formula | C18H19N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-Hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one |
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1. Ouyang L, et al. J Med Chem. 2017 Dec 28;60(24):9990-10012.
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