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Chemical Structure : Factor D inhibitor 6
Catalog No.: PC-62226Not For Human Use, Lab Use Only.
Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM.
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Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM.
Factor D inhibitor 6 is highly selective for human FD, showing no inhibition of factor B; efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes.
Factor D inhibitor 6 inhibits lipopolysaccharide-induced AP activation in FD-humanized mice.
| M.Wt | 484.916 | |
| Formula | C23H22ClFN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Maibaum J, et al. Nat Chem Biol. 2016 Dec;12(12):1105-1110.
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