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Chemical Structure : Factor D inhibitor 7
CAS No.: 1386455-76-0
Catalog No.: PC-62225Not For Human Use, Lab Use Only.
Factor D inhibitor 7 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 50 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | $898 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Factor D inhibitor 7 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 50 nM.
Factor D inhibitor 7 is highly selective for human FD, showing no inhibition of factor B.
Factor D inhibitor 7 efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes.
Factor D inhibitor 7 inhibits lipopolysaccharide-induced AP activation in FD-humanized mice.
| M.Wt | 483.326 | |
| Formula | C21H19BrN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(2-((1R,3S,5R)-3-((6-bromopyridin-2-yl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-indazole-3-carboxamide |
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1. Maibaum J, et al. Nat Chem Biol. 2016 Dec;12(12):1105-1110.
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