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Chemical Structure : Finerenone
Catalog No.: PC-63433Not For Human Use, Lab Use Only.
Finerenone (BAY 94-8862) is a potent, selective, orally available mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM.
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Finerenone (BAY 94-8862) is a potent, selective, orally available mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM; displays excellent selectivity (>500-fold) versus GR, AR, and PR, also shows no L type Ca2+ channel activity; elicits a significant and dose-dependent increase in the urinary sodium/potassium ratio in vivo, with a MED of 0.3 mg kg1 p.o.; exhibits three- to tenfold greater potency and higher efficacy in acute rat natriuresis model compared with eplerenone, demonstrates potential for the treatment of chronic heart failure (CHF).
Heart Failure
Phase 3 Clinical
| M.Wt | 378.432 | |
| Formula | C21H22N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bärfacker L, et al. ChemMedChem. 2012 Aug;7(8):1385-403.
2. Kolkhof P, et al. J Cardiovasc Pharmacol. 2014 Jul;64(1):69-78.
3. Filippatos G, et al. Eur Heart J. 2016 Jul 14;37(27):2105-14.
4. Amazit L, et al. J Biol Chem. 2015 Sep 4;290(36):21876-89.
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