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Chemical Structure : Firzacorvir
Catalog No.: PC-38680Not For Human Use, Lab Use Only.
Firzacorvir (ABI-H2158) is a novel potent HBV core inhibitor structurally distinct from other core inhibitors, ABI-H2158 is a pan-genotypic HBV inhibitor with EC50s ranging from 7.1 to 22 nM across HBV genotypes A-E.
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Firzacorvir (ABI-H2158) is a novel potent HBV core inhibitor structurally distinct from other core inhibitors, ABI-H2158 is a pan-genotypic HBV inhibitor with EC50s ranging from 7.1 to 22 nM across HBV genotypes A-E.
ABI-H2158 inhibited HBV replication by blocking pgRNA encapsidation in induced HepAD38 cells (EC50=22 nM) and had similar potency in HBV-infected HepG2-NTCP cells (EC50=27 nM) and primary human hepatocytes (PHH) (EC50=41 nM).
ABI-H2158 also potently blocked the formation of cccDNA in de novo HBV infections with EC50s of 200 nM in HepG2-NTCP and PHH assays.
ABI-H2158 has dual mechanisms of action, inhibiting both early and late steps of the HBV replication cycle.
| M.Wt | 484.96 | |
| Formula | C18H18ClFN6O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patent, WO2018160878 A1 2018-09-07.
2. Yan R, et al. Antiviral Res. 2022 Dec 9;209:105485.
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