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Chemical Structure : Fruquintinib
CAS No.: 1194506-26-7
Catalog No.: PC-45746Not For Human Use, Lab Use Only.
Fruquintinib (HMPL-013) is a potent and highly selective small molecule inhibitor of VEGFR1/2/3 with IC50 of 33/3/5/0.5 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Fruquintinib (HMPL-013) is a potent and highly selective small molecule inhibitor of VEGFR1/2/3 with IC50 of 33/3/5/0.5 nM, respectively.
Fruquintinib (HMPL-013) weakly inhibits RET, FGFR-1 and c-kit kinases.
Fruquintinib (HMPL-013) demonstrates potent inhibition on VEGF-A dependent KDR phosphorylation in HEK293-KDR cells and VEGF-A induced proliferation in primary HUVECs with IC50 of 0.6 nM and 1.7 nM, respectively.
Fruquintinib (HMPL-013) suppresses tumor growth inhibition in a panel of tumor xenograft and patient derive xenograft models in mouse.
Fruquintinib (HMPL-013) is orally active.
| M.Wt | 393.3927 | |
| Formula | C21H19N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 7.75 mg/mL |
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| Chemical Name/SMILES |
3-Benzofurancarboxamide, 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl- |
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1. Sun Q, et al. Cancer Biol Ther. 2014;15(12):1635-45.
2. Gu Y, et al. Cancer Chemother Pharmacol. 2014 Jul;74(1):95-115.
3. Cao J, et al. Cancer Chemother Pharmacol. 2016 Aug;78(2):259-69.
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