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Chemical Structure : GNE-220
CAS No.: 1199590-75-4
Catalog No.: PC-62936Not For Human Use, Lab Use Only.
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $558 | In stock | |
| 10 mg | $898 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.
GNE-220 alters HUVEC sprout morphology, shifts the distribution of subcellular protrusion and increases total protrusions。
GNE-220 dose-dependently increases the number of β1-integrin in long focal adhesions.
| M.Wt | 438.539 | |
| Formula | C25H26N8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine |
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1. Vitorino P, et al. Nature. 2015 Mar 26;519(7544):425-30.
2. Gao X, et al. Cell Biosci. 2016 Oct 28;6:56. eCollection 2016.
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