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Chemical Structure : GNE-3511
CAS No.: 1496581-76-0
Catalog No.: PC-43286Not For Human Use, Lab Use Only.
GNE-3511 is a potent, selective, orally bioavailable, brain-penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of <0.5 nM, displays >100-fold selectivity over MKK4/7, JNK1/2/3, MLK1/2/3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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GNE-3511 (GNE3511) is a potent, selective, orally bioavailable, brain-penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of <0.5 nM, displays >100-fold selectivity over MKK4/7, JNK1/2/3, MLK1/2/3.
GNE-3511 inhibits p-JNK with IC50 of 30 nM, displays concentration-dependent protection of neurons from degeneration in vitro (DRG IC50=107 nM).
GNE-3511 demonstrates dose-dependent activity in multiple animal models of neurodegenerative disease.
| M.Wt | 440.489 | |
| Formula | C23H26F2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
4-Pyridinecarbonitrile, 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]- |
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1. Patel S, et al. J Med Chem. 2015 Jan 8;58(1):401-18.
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