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Chemical Structure : GRK2-IN-115h hydrochloride
Catalog No.: PC-60353Not For Human Use, Lab Use Only.
A highly potent and selective GRK2 inhibitor with IC50 of 18 nM.
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A highly potent and selective GRK2 inhibitor with IC50 of 18 nM; showes enough selectivity against GRK1/5/6/7, ROCK2 and PKCα with equipotent inhibition to GRK3 (IC50=5.4 nM); potentiates βAR-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol; a novel potential agent for heart failure treatment.
| M.Wt | 502.926 | |
| Formula | C24H22ClF3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Okawa T, et al. J Med Chem. 2017 Aug 24;60(16):6942-6990.
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