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Chemical Structure : GSK-2269557
CAS No.: 1254036-71-9
Catalog No.: PC-45643Not For Human Use, Lab Use Only.
Nemiralisib (GSK-2269557) is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $438 | In stock | |
| 100 mg | Get quote |
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Nemiralisib (GSK-2269557) is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).
Nemiralisib (GSK-2269557) displays >1000 fold selectivity versus other PI3K isoforms.
Nemiralisib (GSK-2269557) inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.2 and 8.1, respectively, in a human lung parenchyma assay.
Nemiralisib (GSK-2269557) shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=67ug/kg).
| M.Wt | 440.5401 | |
| Formula | C26H28N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]- |
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1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.
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