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Chemical Structure : GSK-2878175
Catalog No.: PC-63383Not For Human Use, Lab Use Only.
GSK-2878175 (GSK8175, GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B palm polymerase inhibitor with EC50 of 0.4-9.7 nM.
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GSK-2878175 (GSK8175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM
GSK-2878175 exhibited low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons.
GSK-2878175 displayed a 60-63 h half-life and a robust decrease in viral RNA levels in HCV infected patients relative to GSK5852.
| M.Wt | 568.807 | |
| Formula | C27H23BClFN2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gardner SD, et al. J Viral Hepat. 2018 Jan;25(1):19-27.
2. Chong PY, et al. J Med Chem. 2019 Feb 14. doi: 10.1021/acs.jmedchem.8b01719.
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