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Chemical Structure : GSK-2982772
CAS No.: 1622848-92-3
Catalog No.: PC-63388Not For Human Use, Lab Use Only.
GSK-2982772 is a potent, selective, ATP competitive RIP1 kinase (RIPK1) inhibitor with IC50 of 16 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK-2982772 is a potent, selective, ATP competitive RIP1 kinase (RIPK1) inhibitor with IC50 of 16 nM.
GSK-2982772 inhibits RIP1-dependent inflammatory cytokine MIP-1β production in human whole blood with IC50 of 0.5 nM.
GSK-2982772 reduces spontaneous production of cytokines (IL-1β and IL-6) in a concentration-dependent fashion from ulcerative colitis explant tissue.
GSK-2982772 shows potential for the treatment of inflammatory diseases in vivo.
| M.Wt | 377.404 | |
| Formula | C20H19N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide |
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1. Harris PA, et al. J Med Chem. 2017 Feb 23;60(4):1247-1261.
2. Weisel K, et al. Pharmacol Res Perspect. 2017 Dec;5(6).
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