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Chemical Structure : GSK-588045
Catalog No.: PC-61583Not For Human Use, Lab Use Only.
GSK-588045 is a potent and selective 5-HT1A/B/D receptor antagonist with Ki of 9.5/8.8/9.8, respectively.
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GSK-588045 is a potent and selective 5-HT1A/B/D receptor antagonist with Ki of 9.5/8.8/9.8, respectively; exhibits high selectivity over human hERG potassium channels, favorable pharmacokinetics, and excellent activity in vivo in rodent pharmacodynamic (PD) models; demonstrates potential as a faster acting antidepressant/anxiolytic with reduced side-effect burden.
Anxiety
Phase 1 Clinical
| M.Wt | 468.561 | |
| Formula | C27H28N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bromidge SM, et al. J Med Chem. 2010 Aug 12;53(15):5827-43.
2. Comley RA, et al. Neuropharmacology. 2015 May;92:44-8.
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