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Chemical Structure : GSK-656
Catalog No.: PC-60091Not For Human Use, Lab Use Only.
GSK-656 (Ganfeborole; GSK-3036656, GSK656) is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
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GSK-656 (Ganfeborole; GSK-3036656, GSK656) is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
GSK-656 displays no significant activity for human mitochondrial LeuRS and human cytoplasmic LeuRS (IC50>100 uM).
GSK-656 shows potent antitubercular activity (Mtb H37Rv IC50=0.08 uM) in vitro.
GSK-656 exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models.
| M.Wt | 293.935 | |
| Formula | C10H14BCl2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li X,et al. J Med Chem. 2017 Oct 12;60(19):8011-8026.
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