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GW 275175X

Chemical Structure : GW 275175X

CAS No.: 217950-62-4

GW 275175X (GW275175X)

Catalog No.: PC-61947Not For Human Use, Lab Use Only.

GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation; shows antiviral efficacy against AD169 laboratory strain in DNA hybridization assays with IC50 of 0.7 uM, against 10 clinically relevant HCMV isolates with IC50 of 0.16-2.21 uM, and little or no activity against HSV-1, HSV-2 and varicella zoster virus; inhibits viral DNA maturation in a dose-dependent fashion.

Physicochemical Properties

M.Wt 398.034
Formula C12H11BrCl2N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Bromo-5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole

References

1. Williams SL, et al. Antimicrob Agents Chemother. 2003 Jul;47(7):2186-92.

2. Underwood MR, et al. Antimicrob Agents Chemother. 2004 May;48(5):1647-51.

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