Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Ganaplacide
Catalog No.: PC-61378Not For Human Use, Lab Use Only.
Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
KAF156 demonstrates potent therapeutic activity in mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively.
KAF156 is completely protective as a single oral dose of 10 mg/kg in sporozoite challenge mouse model.
KAF156 shows the potential to treat, prevent, and block the transmission of malaria.
| M.Wt | 411.457 | |
| Formula | C22H23F2N5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kuhen KL, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7.
2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6437-43.
3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166.
4. White NJ, et al. N Engl J Med. 2016 Sep 22;375(12):1152-60.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
