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Chemical Structure : Guanabenz acetate
CAS No.: 23256-50-0
Catalog No.: PC-35504Not For Human Use, Lab Use Only.
Guanabenz acetate (Wytensin, WY-8678 acetate) is a small molecule that binds to PPP1R15A/GADD34, selectively disrupts the stress-induced dephosphorylation of eIF2α.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $88 | In stock | |
| 200 mg | $148 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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Guanabenz acetate (Wytensin, WY-8678 acetate) is a small molecule that binds to PPP1R15A/GADD34, selectively disrupts the stress-induced dephosphorylation of eIF2α.
Guanabenz acetate prolongs eIF2α phosphorylation in human stressed cells, without affecting the related PPP1R15B-phosphatase complex and constitutive protein synthesis.
Guanabenz acetate accelerates ALS-like disease progression in a strain of mutant SOD1 transgenic ALS mice.
Guanabenz acetate exhibits anti-inflammatory activity by increasing in vitro IL-10 production by LPS-stimulated dendritic cells, prevents d-Galactosamine/LPS-induced liver damage and mortality in vivo.
| M.Wt | 291.132 | |
| Formula | C10H12Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, monoacetate (9CI) |
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1. Carrara M, et al. Nat Struct Mol Biol. 2017 Sep;24(9):708-716.
2. Tsaytler P, et al. Science. 2011 Apr 1;332(6025):91-4.
3. Vieira FG, et al. PLoS One. 2015 Aug 19;10(8):e0135570.
4. Perego J, et al. Front Immunol. 2017 Jun 13;8:679.
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