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Chemical Structure : HG-12-6
Catalog No.: PC-36036Not For Human Use, Lab Use Only.
HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM).
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HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM); binds as type II inhibitor with IRAK4 in a “DFG-out” conformation.
| M.Wt | 580.63 | |
| Formula | C29H27F3N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang L, et al. J Biol Chem. 2019 Jan 24. pii: jbc.RA118.005428. doi: 10.1074/jbc.RA118.005428.
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