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Chemical Structure : HLY-78
CAS No.: 854847-61-3
Catalog No.: PC-60196Not For Human Use, Lab Use Only.
HLY-78 is a small molecule activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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HLY-78 is a small molecule activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin.
HLY-78 potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction.
HLY-78 acts synergistically with Wnt in the embryonic development of zebrafish and increases the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb, in zebrafish embryos.
| M.Wt | 267.3 | |
| Formula | C17H17NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
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1. Wang S, et al. Nat Chem Biol. 2013 Sep;9(9):579-85.
2. Chen DZ, et al. J Nat Prod. 2016 Jan 22;79(1):180-8.
3. Guo X, et al. Oncol Res. 2017 May 24;25(5):799-808.
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