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Chemical Structure : HS56
Catalog No.: PC-35492Not For Human Use, Lab Use Only.
HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM).
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HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM).
HS56 displays a high degree of selectivity for DAPKs and Pims against a panel of 468 kinases, with only two off-target interactions TYK2 and GAK.
HS56 also displays no significant inhibition or activation of nicotinic, adrenergic, or muscarinic receptors at 10 uM.
HS56 delayed force onset, decreased contractile force, and reduced LC20 phosphorylation in excised rat caudal arterial VSM tissues.
HS56 lowers blood pressure in spontaneously hypertensive mice without affecting heart rate.
| M.Wt | 317.751 | |
| Formula | C13H8ClN5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carlson DA, et al. Cell Chem Biol. 2018 Jul 4. pii: S2451-9456(18)30220-4.
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