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Chemical Structure : ICA-1
Catalog No.: PC-35336Not For Human Use, Lab Use Only.
ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member.
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ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member.
ICA-1 potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis.
ICA-1 significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
| M.Wt | 336.241 | |
| Formula | C10H17N4O7P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pillai P, et al. Int J Biochem Cell Biol. 2011 May;43(5):784-94.
2. McCray AN, et al. Neurochem Res. 2014 Sep;39(9):1691-701.
3. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.
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