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Chemical Structure : ICSN3250
Catalog No.: PC-35517Not For Human Use, Lab Use Only.
ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
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ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
ICSN3250 is not a kinase inhibitor of mTOR, competes with and displaces phosphatidic acid from the FRB domain in mTOR, thus preventing mTOR activation and leading to cytotoxicity.
ICSN3250 displays no inhibitory capacity towards PI3Kα, β, γ, or δ.
ICSN3250 inhibits mTORC1 by following an unprecedented mechanism that involved its competition with PA at the FRB domain of mTOR to overcome the TSC negative regulation of mTORC1.
ICSN3250 specifically targets cancer cells both in vitro and ex vivo.
| M.Wt | 596.681 | |
| Formula | C31H40N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nguyen TL, et al. Cancer Res. 2018 Jul 27. pii: canres.0232.2018.
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