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Chemical Structure : IKK2-IN-9
Catalog No.: PC-63116Not For Human Use, Lab Use Only.
IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM).
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IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM; dose-dependently inhibist the TNF-α response in murine model of acute inflammation.
| M.Wt | 394.497 | |
| Formula | C20H22N6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dyckman AJ, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6.
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