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Chemical Structure : IRAK-1-4 Inhibitor I
CAS No.: 509093-47-4
Catalog No.: PC-43498Not For Human Use, Lab Use Only.
IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 25 mg | $228 | In stock | |
| 100 mg | $588 | In stock | |
| 500 mg | Get quote |
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IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively; displays IC50 of >10 uM against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60SRC; eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8 in human intestinal epithelial cells.
| M.Wt | ||
| Formula | C20H21N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro- |
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1. Powers JP, et al. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.
2. Bhattacharyya S, et al. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G429-37.
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