Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Imidazole ketone erastin
CAS No.: 1801530-11-9
Catalog No.: PC-36116Not For Human Use, Lab Use Only.
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | $588 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
Imidazole ketone erastin (IKE) potently reduces DLBCL cell number with IC50 of <100 nM (SUDHL6 cell IC50=1 nM).
Imidazole ketone erastin (IKE) exerts antitumor effect by inhibiting system xc-, leading to glutathione depletion (GSH depletion IC50=34 nM, SUDHL6 cells), lipid peroxidation, and the induction of ferroptosis biomarkers both in vitro and in vivo, induced lipid peroxidation in tumor tissue.
| M.Wt | 655.152 | |
| Formula | C35H35ClN6O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(5-(2-(1H-imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one |
|
1. Zhang Y, et al. Cell Chem Biol. 2019 Jan 31. pii: S2451-9456(19)30030-3.
2. Larraufie MH, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4787-4792.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
