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Chemical Structure : Isothiafludine
Catalog No.: PC-63329Not For Human Use, Lab Use Only.
Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM.
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Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM; shows activity against the replication of various drug-resistant HBV mutants, including 3TC/ETV-dual-resistant and ADV-resistant HBV mutants; concentration-dependently reduces the encapsidated HBV pgRNA, resulting in the assembly of replication-deficient capsids in HepG2.2.15 cells; inhibits DHBV DNA replication in the DHBV-infected ducks after oral administration.
HBV Infection
Phase 1 Clinical
| M.Wt | 375.48 | |
| Formula | C18H18FN3OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yang L, et al. Acta Pharmacol Sin. 2014 Mar;35(3):410-8.
2. Yang L, et al. Antiviral Res. 2016 Jan;125:25-33.
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