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Chemical Structure : JC-171
Catalog No.: PC-61787Not For Human Use, Lab Use Only.
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM.
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JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM; interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo; delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE).
| M.Wt | 384.831 | |
| Formula | C16H17ClN2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guo C, et al. ACS Chem Neurosci. 2017 Jul 13. doi: 10.1021/acschemneuro.7b00124.
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