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Chemical Structure : JH-T4
Catalog No.: PC-36070Not For Human Use, Lab Use Only.
JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation.
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JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation; inhibited both the deacetylation and defatty-acylation activity of SIRT2 in vitro with IC50 of 30-50 nM; JH-T4 is the first small molecule inhibitor that can modulate the lysine fatty acylation levels of K-Ras4a. JH-T4 also inhibits SIRT1 and SIRT3 in vitro.
| M.Wt | 597.859 | |
| Formula | C34H51N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Spiegelman NA, et al. ChemMedChem. 2019 Feb 7. doi: 10.1002/cmdc.201800715.
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