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Chemical Structure : JNJ-39393406
Catalog No.: PC-63394Not For Human Use, Lab Use Only.
JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM.
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JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM.
JNJ-39393406 does not act on α4β2, α3β4 or 5-HT3A channels, as well as α4β2, α3β4 or 5 HT3A channels, and it does not interact with a panel of 62 receptors and enzymes.
JNJ-39393406 shows bell-shaped dose-response activity in the auditory evoked potential (AEP) in DBA2 mice (0.63–5 mg/kg s.c., lower and higher doses were inactive), and model for sensory gating and the attentional set-shifting in rats.
| M.Wt | 416.389 | |
| Formula | C19H18F2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Winterer G, et al. Neuropharmacology. 2013 Jan;64:197-204.
2. Perkins KA, et al. Neuropsychopharmacology. 2018 May;43(6):1334-1342.
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