Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JQ1
CAS No.: 1268524-70-4
Catalog No.: PC-43338Not For Human Use, Lab Use Only.
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 100 mg | $358 | In stock | |
| 500 mg | $1058 | In stock | |
| 1 g | $1680 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively; induces rapid expression of keratin in treated NMC 797 cells, displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.
| M.Wt | 456.9882 | |
| Formula | C23H25ClN4O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 45 mg/mL |
|
| Chemical Name/SMILES |
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)- |
|
1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.
2. Matzuk MM, et al. Cell. 2012 Aug 17;150(4):673-84.
3. Peirs S, et al. Leukemia. 2017 Oct;31(10):2037-2047.
4. Tögel L, et al. Mol Cancer Ther. 2016 Jun;15(6):1217-26.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
