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Chemical Structure : JTT-553 benzosulfonate
Catalog No.: PC-62952Not For Human Use, Lab Use Only.
JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM).
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JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM); suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats; also reduces daily food intake and body weight gain in diet-induced obesity rats.
Obesity
Phase 1 Discontinued
| M.Wt | 646.682 | |
| Formula | C31H33F3N4O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9.
2. Tomimoto D, et al. J Pharmacol Sci. 2015 Sep;129(1):51-8.
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