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Chemical Structure : K-604
CAS No.: 217094-32-1
Catalog No.: PC-62954Not For Human Use, Lab Use Only.
K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | $858 | In stock | |
| 200 mg | Get quote | ||
| 1 | Get quote |
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K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
K-604 inhibits cholesterol esterification in human monocyte-derived macrophages with IC50 of 60 nM, enhances cholesterol efflux from THP-1 macrophages to HDL3 or apolipoprotein A-I.
K-604 suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.
| M.Wt | 575.63 | |
| Formula | C23H32Cl2N6OS3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[2-(1H-Benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide dihydrochloride |
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1. Ikenoya M, et al. Atherosclerosis. 2007 Apr;191(2):290-7.
2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.
3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.
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