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Chemical Structure : KAR-5585
Catalog No.: PC-62808Not For Human Use, Lab Use Only.
KAR-5585 (Rodatristat) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice.
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KAR-5585 (Rodatristat) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice; generates high and sustained systemic exposure of the active parent KAR5417 in rats and dogs; orally bioavailable.
Hypertension
Phase 1 Clinical
| M.Wt | 590.044 | |
| Formula | C29H31ClF3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goldberg DR, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):413-419.
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