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Chemical Structure : KBFM123
Catalog No.: PC-35613Not For Human Use, Lab Use Only.
KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM).
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KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM).
KBFM123 interacts directly with a hydrophobic pocket located between Switch I and Switch II and allosterically inhibits the effector interaction by inducing conformational changes in Switch I and its flanking region in the β2-strand, which are directly involved in recognition of the effector molecules including c-Raf-1.
KBFM123 is a promising scaffold for the development of Ras inhibitors.
| M.Wt | 271.316 | |
| Formula | C16H17NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matsumoto S, et al. Biochemistry. 2018 Aug 24. doi: 10.1021/acs.biochem.8b00680.
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