Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : KN-62
CAS No.: 127191-97-3
Catalog No.: PC-43468Not For Human Use, Lab Use Only.
KN-62 is a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK II) with Ki of 900 nM for rat brain CaMK II.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
KN-62 is a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK II) with Ki of 900 nM for rat brain CaMK II.
KN-62 potently antagonizes ATP-stimulated Ba2+ influx into fura-2 loaded human lymphocytes with IC50 of 12.7 nM, inhibits ATP-stimulated ethidium+ uptake with IC50 of 13.1 nM.
KN-62 causes hypertension and tachycardia in rats, associated with the diminished rate of GABA release in cerebrospinal fluid.
| M.Wt | ||
| Formula | C38H35N5O6S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester |
|
1. Tokumitsu H, et al. J Biol Chem. 1990 Mar 15;265(8):4315-20.
2. Ishikawa N, et al. J Pharmacol Exp Ther. 1990 Aug;254(2):598-602.
3. Ito I, et al. Neurosci Lett. 1991 Jan 2;121(1-2):119-21.
4. Gargett CE, et al. Br J Pharmacol. 1997 Apr;120(8):1483-90.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
