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Chemical Structure : KRAS inhibitor Cmpd2
Catalog No.: PC-35593Not For Human Use, Lab Use Only.
KRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.
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KRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro; inhibits cell proliferation in SW1990 cells with EC50 of 2.7 uM; the potency of Cmpd2 was strongly enhanced when prenylated K-RAS4B is associated with a lipid bilayer.
| M.Wt | 446.773 | |
| Formula | C21H21BrClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fang Z, et al. Cell Chem Biol. 2018 Aug 14. pii: S2451-9456(18)30261-7.
2. Jansen JM, et al. PLoS One. 2017 Apr 6;12(4):e0174706.
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