Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : KW-2478
CAS No.: 819812-18-5
Catalog No.: PC-61250Not For Human Use, Lab Use Only.
KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo.
KW-2478 demonstrates antiproliferative activities against human MM cells, OPM-2/GFP, KMS-11, RPMI 8226, and NCI-H929 with IC50 of 0.30, 0.34, 0.39, and 0.12 uM respectively, associated with degradation of well-known client proteins as well as FGFR3, c-Maf, and cyclin D1.
KW-2478 suppresses tumor growth in NCI-H929 models.
| M.Wt | 611.129 | |
| Formula | C30H43ClN2O9 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-{2-ethyl-3,5dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl}-N,N-bis(2-methoxyethyl)acetamide monohydrochloride |
|
1. Nakashima T, et al. Clin Cancer Res. 2010 May 15;16(10):2792-802.
2. Ishii T, et al. Blood Cancer J. 2012 Apr;2(4):e68.
3. Yong K, et al. Br J Cancer. 2016 Jan 12;114(1):7-13.
4. Agatsuma T, et al. Bioorg Med Chem. 2002 Nov;10(11):3445-54.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
