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Chemical Structure : Kinase inhibitor C1
Catalog No.: PC-70141Not For Human Use, Lab Use Only.
A potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM.
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A potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM; causes mitotic arrest and subsequent cellular apoptosis in vitro; strongly induces tumor cell apoptosis in slice cultures of GBM surgical specimens and attenuates growth of mouse intracranial tumors derived from GSCs; also inhibits Aurora A/B/C (IC50=61/31/124 nM), and Chk1 (IC50=262 nM); a multi-kinase inhibitor.
| M.Wt | 292.338 | |
| Formula | C18H16N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Minata M, et al. PLoS One. 2014 Apr 16;9(4):e92546.
2. Hoang TM, et al. Cell Cycle. 2009 Mar 1;8(5):765-72.
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