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Chemical Structure : L-α-Hydroxyglutaric acid disodium salt
Catalog No.: PC-62978Not For Human Use, Lab Use Only.
L-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate.
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L-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate;L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 0.628 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
| M.Wt | ||
| Formula | C5H6Na2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
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