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Chemical Structure : L 873724
Catalog No.: PC-62964Not For Human Use, Lab Use Only.
L 873724 is a potent and selective non-basic cathepsin K inhibitor with IC50 of 0.2 nM, shows no significant potency against Cat B, L, and S (IC50= 5239, 264, and 178 nM).
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L 873724 is a potent and selective non-basic cathepsin K inhibitor with IC50 of 0.2 nM, shows no significant potency against Cat B, L, and S (IC50= 5239, 264, and 178 nM).
L 873724 demonstrates excellent pharmacokinetics and efficacy in an ovariectomized (OVX) rhesus monkey model.
| M.Wt | 481.534 | |
| Formula | C23H26F3N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li CS, et al. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1985-9.
2. Desmarais S, et al. Mol Pharmacol. 2008 Jan;73(1):147-56.
3. Pennypacker BL, et al. BMC Musculoskelet Disord. 2013 Dec 9;14:344.
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