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Chemical Structure : LB-100
CAS No.: 1632032-53-1
Catalog No.: PC-45470Not For Human Use, Lab Use Only.
LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor.
LB100 exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.
LB100 synergistically enhances the activity of doxorubicin and induces expression of HIF-1α and VEGF.
LB100 significantly enhances tumor growth inhibition by cisplatin in vivo.
| M.Wt | 268.3089 | |
| Formula | C13H20N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 48 mg/mL; DMSO: < 2.9 mg/mL |
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| Chemical Name/SMILES |
7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[(4-methyl-1-piperazinyl)carbonyl]-, (1R,4S)-rel- |
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1. Bai XL, et al. Mol Cancer Ther. 2014 Aug;13(8):2062-72.
2. Chang KE, et al. Mol Cancer Ther. 2015 Jan;14(1):90-100.
3. Gordon IK, et al. Mol Cancer Ther. 2015 Jul;14(7):1540-7.
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