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Chemical Structure : LHF-535
Catalog No.: PC-35909Not For Human Use, Lab Use Only.
LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3 nM.
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LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3 nM; LHF-535 has sub-nanomolar potency against the viral envelope glycoproteins from all Lassa virus lineages, with the exception of the glycoprotein from the LP strain from lineage I, which was 100-fold less sensitive than that of other strains; potently inhibited Junín virus, but not Candid#1 in virus-yield reduction assays; protects mice in a lethal Tacaribe virus model at 10 mg/kg.
Other Indication
Phase 1 Clinical
| M.Wt | 412.533 | |
| Formula | C27H28N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Madu IG, et al. PLoS Pathog. 2018 Dec 21;14(12):e1007439.
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