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Chemical Structure : LLS2
Catalog No.: PC-61647Not For Human Use, Lab Use Only.
LLS2 is a novel potent Galectin-1 (Gal1) inhibitor that decreases membrane-associated H-Ras and K-Ras and contributed to the suppression of pErk pathway.
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LLS2 is a novel potent Galectin-1 (Gal1) inhibitor that decreases membrane-associated H-Ras and K-Ras and contributed to the suppression of pErk pathway; kills SKOV3, HT29, PC3, XPA3, MCF7, and A549 with an IC50 of 11.7, 24.5, 28.2, 20.9, 23.2 and 34.3 uM respectively; exhibits synergistic activity against several human cancer cell lines, significantly inhibits the growth of ovarian cancer xenografts in athymic mice combined with paclitaxel.
| M.Wt | 809.693 | |
| Formula | C40H40Cl2F2N6O6 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Shih TC, et al. Mol Cancer Ther. 2017 Jul;16(7):1212-1223.
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