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Chemical Structure : LLY-283
CAS No.: 2040291-27-6
Catalog No.: PC-63461Not For Human Use, Lab Use Only.
LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.
LLY-283 displays excellent against other arginine methyltransferases including the closely related PRMT7 and the type II PRMTs such as PRMT4 and 6.
LLY-283 decreases SmBB’-Rme2s levels in MCF7 cells with IC50 of 25 nM, also inhibits the PRMT5 mediated regulation of the splicing of MDM4.
LLY-283 inhibits proliferation of A375 cells with IC50 of 45.6 nM.
LLY-283 inhibits Tumor growth in mouse xenograft (A375, 20 mg/kg; QD).
| M.Wt | 342.36 | |
| Formula | C17H18N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol |
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1. Zahid Q. Bonday, et al. ACS Med. Chem. Lett. 2018. DOI: 10.1021/acsmedchemlett.8b00014.
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