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Chemical Structure : LSN 3213128
Catalog No.: PC-62007Not For Human Use, Lab Use Only.
LSN 3213128 is a novel potent, selective and orally-bioavailable antifolate with potent and specific inhibitory activity for AICARFT.
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LSN 3213128 is a novel potent, selective and orally-bioavailable antifolate with potent and specific inhibitory activity for AICARFT.
LSN 3213128 treatment results in dramatic elevation of 5-aminoimidazole 4-carboxamide ribonucleotide (ZMP) and growth inhibition in NCI-H460 and MDA-MB-231met2 cancer cell lines.
LSN 3213128 demonstrates tumor growth inhibition in a murine based xenograft model of triple negative breast cancer (TNBC).
Aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) is an enzyme in the purine biosynthetic pathway.
| M.Wt | 409.45 | |
| Formula | C17H16FN3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fales KR, et al. J Med Chem. 2017 Oct 26. doi: 10.1021/acs.jmedchem.7b01046.
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